Why the study?
Does dermatan sulphate prevent postoperative deep vein thrombosis in patients aged 40 years or over undergoing elective major general surgical operations?
Population
324 patients aged 40 years or over undergoing elective major general surgical operations
Comparison
Dermatan sulphate 100 mg intramuscularly once a… vs Unfractionated calcium heparin 5000 units…
Design
RCT, randomized
Follow-up
until discharge (with 3-month mortality follow-up)
Authors
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Dermatan sulphate may be considered for postoperative DVT prophylaxis in major surgery; extends randomized evidence for lower-bleeding glycosaminoglycan alternatives to UFH.
Does dermatan sulphate prevent postoperative deep vein thrombosis in patients aged 40 years or over undergoing elective major general surgical operations?
Dermatan sulphate provides similar efficacy for DVT prophylaxis as unfractionated heparin but with a significantly lower risk of bleeding in patients undergoing major general surgery.
Prandoni et al. (1992) studied this question.
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