What question did this study set out to answer?

To evaluate the antithrombotic efficacy and bleeding risks of dermatan sulphate and heparan sulphate compared to unfractionated heparin in a rat model of venous thrombosis.

April 23, 2009Haemostasis

Antithrombotic Properties of Dermatan Sulphate in a Rat Venous Thrombosis Model

View Full Paper

Ask AI

Bookmark

Authors

AMAntonio MaggiFondazione Poliambulanza Istituto Ospedaliero MAMarzia AbbadiniMario Negri Institute for Pharmacological Research PPP.G. PagellaMediolanum Farmaceutici (Italy)

Discussion

Member takes

Implication

Animal experiment demonstrates antithrombotic efficacy of dermatan sulphate with minimal bleeding risk in rats, suggesting safer alternatives to heparin.

Key Points

To evaluate the antithrombotic efficacy and bleeding risks of dermatan sulphate and heparan sulphate compared to unfractionated heparin in a rat model of venous thrombosis.
Tested dermatan sulphate (DS) and heparan sulphate (HS) at doses ranging from 0.25 to 4 mg/kg body weight in an experimental stasis-induced venous thrombosis rat model.
Compared outcomes against unfractionated heparin administered at 0.5 to 2 mg/kg body weight.
Assessed coagulation parameters (activated partial thromboplastin time, thrombin time, and anti-Xa assays) alongside bleeding times evaluated via template and tail transection methods.
Dermatan sulphate inhibited thrombus formation by 70% without significantly prolonging bleeding times measured by template or tail transection.
Antithrombotic effects of DS operated independently of traditional anticoagulant metrics including APTT, TT, and anti-Xa activity.
Heparan sulphate and equipotent doses of unfractionated heparin significantly prolonged bleeding times, indicating an elevated haemorrhagic risk compared to DS.

Cite This Study

Maggi et al. (2009) studied this question.

synapsesocial.com/papers/6a7484b7cbb3fa1e5bdbd37a https://doi.org/10.1159/000215765

View Full Paper

Ask AI

Bookmark

Implication

Animal experiment demonstrates antithrombotic efficacy of dermatan sulphate with minimal bleeding risk in rats, suggesting safer alternatives to heparin.

Antithrombotic Properties of Dermatan Sulphate in a Rat Venous Thrombosis Model

Discussion

Member takes

Implication

Key Points

Cite This Study

Antithrombotic Properties of Dermatan Sulphate in a Rat Venous Thrombosis Model

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider