Key result
Sulfated polysaccharides dosed for ~75% thrombus inhibition show varying effectiveness across different thrombogenic stimuli.
Why the study?
Does the antithrombotic effectiveness of heparin, pentosan polysulfate, and dermatan sulfate vary depending on the thrombogenic stimulus in a rabbit model?
Population
rabbit jugular vein hypercoagulation/stasis model
Design
Preclinical
Authors
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Stimulus-specific antithrombotic effects seen in rabbits; hypothesis-generating and should not yet guide clinical anticoagulant selection.
Does the antithrombotic effectiveness of heparin, pentosan polysulfate, and dermatan sulfate vary depending on the thrombogenic stimulus in a rabbit model?
The antithrombotic efficacy of specific sulfated polysaccharides varies depending on the specific stimulus initiating thrombus formation.
Ryn-McKenna et al. (1989) studied Thrombus formation. Sulfated polysaccharides (heparin, pentosan polysulfate, dermatan sulfate) was evaluated on Inhibition of thrombus formation. Sulfated polysaccharides dosed to inhibit thromboplastin-induced thrombus by ~75% showed varying effectiveness depending on whether the stimulus was thrombin, factor Xa, or tissue thromboplastin.
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