Population
In vitro and ex vivo plasma samples, and experimental venous thrombosis model
Comparison
Dermatan sulphate (DS) up to 1.25 mg/kg vs Unfractionated heparin
Design
Preclinical
Authors
Loading...
DS underperforms UFH in this animal stasis model; leaves open dose optimization and human translation.
Dermatan sulphate has antithrombotic activity but is less effective than unfractionated heparin in inhibiting thrombin generation and preventing experimental thrombosis.
Merton et al. (1987) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: