Why the study?
Do diets of differing macronutrient composition (high-fat vs combined high-fat/high-carbohydrate) differentially affect vascular function in male Wistar rats?
Population
Male Wistar rats (n = 6/group, total n=18)
Comparison
Chow supplemented with chocolate biscuit or a… vs Chow as control diet
Design
Preclinical
Follow-up
10 weeks
Authors
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Combined high-fat/high-carb diets may worsen vascular impairment beyond high-fat alone in rats; leaves open human relevance.
Do diets of differing macronutrient composition (high-fat vs combined high-fat/high-carbohydrate) differentially affect vascular function in male Wistar rats?
Combining potentially atherogenic macronutrients (high-fat/high-carbohydrate) induces more extensive vascular impairment than high-fat alone in a rat model, likely due to more marked dyslipidemia.
Fatani et al. (2007) studied this question.
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