What does this research mean for the field?

A high-fat diet causes progressive impairment of coronary vascular endothelial function that persists and is difficult to reverse even after dietary correction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 9, 2014ObesityOpen Access

Progression and reversal of coronary and mesenteric vascular dysfunction associated with obesity

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Why the study?

Does a high fat diet cause progressive and reversible microvascular complications in Sprague-Dawley rats?

Population

Sprague-Dawley rats, 10 weeks of age

Design

Preclinical

Follow-up

Up to 32 weeks (plus 8 weeks reversal)

Authors

TKTravis L. KleinschmidtUniversity of Iowa COChristine L. OltmanUniversity of Iowa

Discussion

Member takes

Implication

Hypothesis-generating for persistent diet-induced coronary endothelial dysfunction; should not yet change human practice.

Structured PICO

Does a high fat diet cause progressive and reversible microvascular complications in Sprague-Dawley rats?

Population

Sprague-Dawley rats, 10 weeks of age

Intervention

High fat diet (45% kcal fat) for up to 32 weeks, with an 8-week diet reversal phase

Outcome

Vascular reactivity of aorta and small coronary and mesenteric vesselssurrogate

A high-fat diet induces progressive coronary endothelial dysfunction in rats that persists even after dietary reversal.

Cite This Study

Kleinschmidt et al. (2014) studied this question.

synapsesocial.com/papers/6a1d1c97ba3016ff712f1348 https://doi.org/10.1002/oby.20837

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Progression and reversal of coronary and mesenteric vascular dysfunction associated with obesity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Progression and reversal of coronary and mesenteric vascular dysfunction associated with obesity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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