Key result
High-fat diet worsens obesity, hypertension, and vascular dysfunction in obesity-prone rats.
Why the study?
The genetic background of obesity-prone rats may predispose to physiologic, metabolic, and microvascular dysfunction exacerbated by a high saturated fat diet.
Does a high-fat diet exacerbate physiologic, metabolic, and microvascular dysfunction in obesity-prone compared to obesity-resistant rats?
Population
Male obesity-prone and obesity-resistant rats
Comparison
Diet containing 45% kcal fat vs diet containing 10% kcal fat
Design
Preclinical study
Follow-up
42 weeks
Authors
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Genetic predisposition may drive hypertension and vascular dysfunction in obesity models; extends rodent evidence but leaves human translation open.
Does a high-fat diet exacerbate physiologic, metabolic, and microvascular dysfunction in obesity-prone compared to obesity-resistant rats?
Genetic predisposition to obesity in rats leads to hypertension and vascular dysfunction even on a normal diet, which is exacerbated by a high-fat diet.
Dake et al. (2015) studied Obesity. High-fat diet vs. Chow diet (10% kcal fat) was evaluated on Weight, blood pressure, glucose clearance, and vascular dysfunction. Obesity-prone rats developed greater obesity, hypertension, and vascular dysfunction on a normal diet compared to obesity-resistant rats, which was further augmented by a high-fat diet.
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