What does this research mean for the field?

The 90-day incidence of venous thromboembolism following total hip replacement with routine pharmacological thromboprophylaxis is approximately 1%, with prior venous thromboembolism, cardiovascular disease, and high comorbidity significantly increasing the risk. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify patient-related risk factors for postoperative venous thromboembolism within ninety days among individuals undergoing primary total hip replacement with routine pharmacological thromboprophylaxis.

September 1, 2010Journal of Bone and Joint Surgery

Risk Factors for Venous Thromboembolism in Patients Undergoing Total Hip Replacement and Receiving Routine Thromboprophylaxis

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Why the study?

What are the risk factors for venous thromboembolism in patients undergoing total hip replacement and receiving routine thromboprophylaxis?

Key Points

To identify patient-related risk factors for postoperative venous thromboembolism within ninety days among individuals undergoing primary total hip replacement with routine pharmacological thromboprophylaxis.
Nationwide population-based cohort study analyzing 67,469 primary total hip replacement procedures with pharmacological thromboprophylaxis in Denmark from 1995 to 2006.
Tracked hospitalizations for symptomatic deep venous thrombosis and nonfatal pulmonary embolism across a 90-day postoperative window.
Hospitalization for venous thromboembolism occurred in 1.02% of procedures (686 of 67,469; median 22 days), including deep venous thrombosis in 0.7% (n=499) and nonfatal pulmonary embolism in 0.3% (n=205).
Prior venous thromboembolism strongly predicted recurrence (RR = 8.09; 95% CI, 6.07 to 10.77), with elevated risk also seen for high Charlson comorbidity index scores (adjusted RR = 1.45; 95% CI, 1.02 to 2.05) and cardiovascular disease (RR = 1.40; 95% CI, 1.15 to 1.70).
Patients with rheumatoid arthritis exhibited a significantly reduced relative risk of venous thromboembolism compared with those undergoing surgery for primary osteoarthritis (adjusted RR = 0.47; 95% CI, 0.25 to 0.90).

Structured PICO

What are the risk factors for venous thromboembolism in patients undergoing total hip replacement and receiving routine thromboprophylaxis?

Population

67,469 patients who underwent primary total hip replacement and received pharmacological thromboprophylaxis in Denmark from 1995 to 2006.

Intervention

Patient-related risk factors (age, sex, indication, comorbidity history)

Outcome

Hospitalization with venous thromboembolism within ninety days of surgeryhard clinical

The 90-day incidence of VTE after total hip replacement with routine thromboprophylaxis is approximately 1%, with prior VTE and cardiovascular disease being significant risk factors.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Prior VTE identifies high-risk THR patients despite prophylaxis; leaves open whether tailored regimens improve outcomes.

Cite This Study

Pedersen et al. (2010) studied this question.

synapsesocial.com/papers/6a1d1db71c2cbcb15c5dc9d8 https://doi.org/10.2106/jbjs.i.00882

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Risk Factors for Venous Thromboembolism in Patients Undergoing Total Hip Replacement and Receiving Routine Thromboprophylaxis

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Risk Factors for Venous Thromboembolism in Patients Undergoing Total Hip Replacement and Receiving Routine Thromboprophylaxis

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider