What does this research mean for the field?

Lower prognostic nutritional index (PNI) scores at discharge are significantly associated with higher long-term all-cause mortality in pneumonia-induced sepsis survivors, outperforming other established nutritional and inflammatory indicators. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to assess the prognostic value of the prognostic nutritional index (PNI) for long-term all-cause mortality in pneumonia-induced sepsis survivors.

June 1, 2026Frontiers in NutritionOpen Access

Prognostic nutritional index at discharge as a practical bedside tool for long-term all-cause mortality risk in pneumonia-induced sepsis survivors

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Authors

ZZZhenwei ZhaiThe People's Hospital of Guangxi Zhuang Autonomous Region JHJunyu HeThe People's Hospital of Guangxi Zhuang Autonomous Region JSJingxia SunThe People's Hospital of Guangxi Zhuang Autonomous Region

Discussion

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Implication

Randomized trial evaluates long-term mortality risk in pneumonia-induced sepsis survivors, suggesting PNI as a useful clinical tool.

Key Points

This study aims to assess the prognostic value of the prognostic nutritional index (PNI) for long-term all-cause mortality in pneumonia-induced sepsis survivors.
Ambispective longitudinal cohort study involving 461 pneumonia-induced sepsis survivors with median follow-up of 36 months.
Participants were stratified into tertiles based on discharge PNI scores to evaluate its association with long-term mortality.
Comparative analysis against established indicators like CONUT, mGPS, BAR, NLR, and PLR was conducted.
Lower PNI levels showed a significant association with higher cumulative mortality (log-rank, p < 0.001).
Participants in the lowest PNI tertile had a 54.8% higher mortality risk compared to the highest tertile (p for trend = 0.043).
ROC curve analysis determined a PNI clinical diagnostic cutoff of 39.00 for long-term mortality, with AUC of 0.672 (p < 0.001).

Cite This Study

Zhai et al. (2026) studied this question.

synapsesocial.com/papers/6a1d208702fbce9130636ec0 https://doi.org/10.3389/fnut.2026.1813273

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Prognostic nutritional index at discharge as a practical bedside tool for long-term all-cause mortality risk in pneumonia-induced sepsis survivors

Discussion

Member takes

Implication

Key Points

Cite This Study

Prognostic nutritional index at discharge as a practical bedside tool for long-term all-cause mortality risk in pneumonia-induced sepsis survivors

Discussion

Member takes

Implication

Key Points

Cite This Study

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