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December 9, 2025Scientific ReportsOpen Access

Prognostic nutritional indices predict 60 day mortality in ICU patients with sepsis

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Authors

JFJinyan FangZhejiang Chinese Medical UniversityYLYuanhan LinZhejiang Chinese Medical UniversityLZLinjun ZhaoZhejiang Chinese Medical University

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Overview

This analysis predicts mortality risk in sepsis patients using nutritional status, highlighting the benefit of nutritional interventions.

Key Points

  • To evaluate the role of Prognostic Nutritional Index and Geriatric Nutritional Risk Index in predicting 60-day mortality in sepsis patients.
  • Analyzed data from MIMIC-IV database with 1649 sepsis patients.
  • Performed Kaplan-Meier survival analysis and multivariate Cox regression analysis.
  • Conducted restricted cubic spline analysis to assess correlation between PNI and mortality risk.
  • Stratified patients based on age, comorbidities, and treatments.
  • Patients in high-score PNI and GNRI groups showed a 53% reduction in mortality risk.
  • Kaplan-Meier analysis revealed significant differences in survival rates between PNI and GNRI tertiles.
  • Subgroup analysis showed PNI had significant protective effects in patients aged ≤ 65 years and treated with β-lactam antibiotics.

Cite This Study

Fang et al. (2025) studied this question.

synapsesocial.com/papers/69401efa2d562116f28f98d0https://doi.org/10.1038/s41598-025-28609-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic nutritional index at discharge as a practical bedside tool for long-term all-cause mortality risk in pneumonia-induced sepsis survivors2026
  2. 2Nonlinear correlation between prognostic nutritional indices (PNI) and patients with sepsis: a retrospective study based on the MIMIC database.2024
  3. 3The V-shaped association between the ratio of neutrophil counts to prognostic nutritional index and 30-, 60-, and 90-day mortality in elderly critically ill patients aged 65 and older with sepsis: a retrospective study based on the MIMIC database2025
  4. 4Comparative Prognostic Accuracy of Objective Nutritional Indices in Critically Ill Patients with Sepsis: A Systematic Review and Meta-Analysis2026 · 2 citations
  5. 5Prognostic Nutritional Index as a Predictor of 90-Day Mortality in Surgical Sepsis Patients with Acute Kidney Injury—A Retrospective Cohort Study Based on the MIMIC-IV Database2026