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May 20, 2026Journal of Clinical MedicineOpen Access

Comparative Prognostic Accuracy of Objective Nutritional Indices in Critically Ill Patients with Sepsis: A Systematic Review and Meta-Analysis

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Authors

YYYi YangBGI Group (China)YZYu ZhangSouth China Agricultural UniversityTQTian‐Yi QuSichuan University

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Implication

Systematic review evaluates nutritional indices for predicting mortality in critically ill sepsis patients, suggesting varying accuracy.

Key Points

  • This research aims to evaluate the effectiveness of various nutritional indices in predicting mortality among patients with sepsis.
  • Conducted a systematic review and meta-analysis on studies from PubMed, Embase, and Web of Science.
  • Pooled odds ratios, hazard ratios, and diagnostic accuracy measures were calculated using random-effects models for 22 studies.
  • Subgroup and sensitivity analyses were performed to explore heterogeneity and test robustness.
  • Higher mNUTRIC and NUTRIC scores were linked to increased mortality with ORs of 3.10 (95% CI 1.39–6.89) and 4.54 (95% CI 2.13–9.66) respectively.
  • A higher PNI was associated with lower mortality (OR 0.64, 95% CI 0.50–0.83; HR 0.66, 95% CI 0.54–0.81).
  • Better discrimination for mortality was noted in mNUTRIC compared to PNI (AUC 0.84 vs. 0.74).

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5025f03e14405aa9bd1ahttps://doi.org/10.3390/jcm15103885
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Value of Nutritional Risk Scores in Septic ICU Patients: A Survival Analysis Using mNUTRIC, PNI, and CONUT2026 · 1 citations
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  3. 3Association of malnutrition status with 30-day mortality in patients with sepsis using objective nutritional indices: a multicenter retrospective study2024 · 29 citations
  4. 4Relation between nutritional status on clinical outcomes of critically ill patients: emphasizing nutritional screening tools in a prospective cohort investigation2024 · 23 citations
  5. 5Comparative prognostic value of nutrition–inflammation indices for 1-year mortality in elderly intensive care unit patients: a retrospective observational study based on MIMIC-IV database2026