Elevated neutrophil-to-lymphocyte ratio (OR 2.495), neutrophils, platelet count, albumin, and triglycerides were independently associated with increased hypertension risk in children with obesity.
Cross-Sectional (n=756)
No
What factors are associated with hypertension in children and adolescents with obesity?
Elevated levels of neutrophils, NLR, platelets, albumin, and triglycerides are independently associated with an increased risk of hypertension in children with obesity.
Effect estimate: OR 2.495 (95% CI 1.158-5.377)
p-value: p=0.020
Introduction Childhood hypertension and obesity are among the most prevalent health conditions worldwide, with obesity increasing the risk of hypertension in children. However, there has been limited focus on children with obesity. Methods To identify the risk factors of hypertension in children with obesity and the relationship between them, we collected information from children who were registered at the Child Health Development Center of Hunan Children's Hospital between October 2021 and December 2023. Logistic regression combined with restricted cubic spline was used to examine the relationship between the variables and hypertension in children with obesity. Results A total of 756 children with obesity were included in the study. The detection rate of hypertension in children with obesity was 20.6%, with a mean age of 11.9±2.0 years. The logistic regression indicated that neutrophils (NE), the ratio of neutrophils to lymphocytes (NLR), platelet count (PLT), albumin (ALB) and triglycerides (TG) were independent risk factors for hypertension in children with obesity. Restricted cubic spline curves showed NE, NLR, PLT, ALB and TG increasing linearly with the risk of hypertension. There was a significant linear relationship between NE, NLR, ALB, TG and systolic blood pressure (SBP)/diastolic blood pressure (DBP). A nonlinear dose-response relationship is observed between PLT and SBP, but no dose-response relationship between PLT and DBP. Discussion Elevated levels of NE, NLR, PLT, ALB, and TG are associated with hypertension in children with obesity. Future studies need normal-weight controls to better examine these links.
Zhou et al. (Thu,) conducted a cross-sectional in Hypertension in children with obesity (n=756). Elevated neutrophil-to-lymphocyte ratio (NLR) vs. Lower neutrophil-to-lymphocyte ratio (NLR) was evaluated on Hypertension (OR 2.495, 95% CI 1.158-5.377, p=0.020). Elevated neutrophil-to-lymphocyte ratio (OR 2.495), neutrophils, platelet count, albumin, and triglycerides were independently associated with increased hypertension risk in children with obesity.