Key result
Day 3 postoperative C-reactive protein-to-albumin ratio predicts ~91% higher anastomotic leakage risk after colorectal surgery.
Why the study?
Anastomotic leakage is a severe postoperative complication, making early identification of patients at risk essential to improve postoperative outcomes.
Do postoperative day 3 biomarkers predict anastomotic leakage in patients undergoing colorectal cancer surgery?
Cohort (n=166)
No
Do postoperative day 3 biomarkers predict anastomotic leakage in patients undergoing colorectal cancer surgery?
Effect estimate: OR 1.91 (95% CI 1.520-2.408)
p-value: p=<0.001
Postoperative day 3 biomarkers are being evaluated for their ability to predict anastomotic leakage after colorectal cancer surgery.
May facilitate early risk stratification after colorectal surgery; hypothesis-generating and requires prospective validation before clinical use.
Introducere: Fistula anastomotică (FA) reprezintă o complicaţie postoperatorie severă, în special în chirurgia oncologică digestivă, cu impact major atât asupra pacienţilor, cât şi asupra chirurgilor.Având în vedere severitatea consecinţelor clinice, indentificarea precoce a pacienţilor cu risc de FA este esenţială pentru îmbunătăţirea rezultatelor postoperatorii.
No takes yet. Share an insight, caveat, or question.
Ghirlea et al. (2026) conducted a cohort in Colorectal cancer (n=166). Postoperative day 3 C-reactive protein-to-albumin ratio (CAR) vs. Other biomarkers (CRP, LCR, Albumin, NLR, Leukocytes) was evaluated on Anastomotic leakage (OR 1.91, 95% CI 1.520-2.408, p=<0.001). Postoperative day 3 C-reactive protein-to-albumin ratio (CAR) independently predicted anastomotic leakage after colorectal cancer surgery (OR 1.91) with high discriminatory performance.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: