Catalytic Aerobic Sulfonyloximation of Alkenes Enabled by the Nitric Oxide-Donor Role of 2-Nitropropane

Q: What does this research mean for the field?

2-Nitropropane functions as an effective nitric oxide donor to enable the catalytic aerobic sulfonyloximation of alkenes, producing structurally diverse β-sulfonyl oximes under mild conditions. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Pradip Ramdas Thorve; Hyeonmin Jo; Hun Young Kim; Kyungsoo Oh

doi:10.1021/acs.orglett.6c01681

May 29, 2026Organic Letters

Catalytic Aerobic Sulfonyloximation of Alkenes Enabled by the Nitric Oxide-Donor Role of 2-Nitropropane

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Key Points

The aim is to explore the catalytic aerobic sulfonyloximation of alkenes using 2-nitropropane as a nitric oxide donor.
Utilized 2-nitropropane to donate nitric oxide during reactions.
Employed mild conditions for the synthesis process.
Generated a variety of structurally diverse β-sulfonyl oximes.
Achieved a broad substrate scope with successful formation of β-sulfonyl oximes.
Demonstrated potential for nitrous oxide incorporation in radical reactions.

Implication

This trial demonstrates controlled nitric oxide incorporation in radical transformations of alkenes, suggesting expanded synthetic utility.

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Cite This Study

Thorve et al. (2026) studied this question.

synapsesocial.com/papers/6a1d21ba02fbce9130637ba0 https://doi.org/10.1021/acs.orglett.6c01681

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Catalytic Aerobic Sulfonyloximation of Alkenes Enabled by the Nitric Oxide-Donor Role of 2-Nitropropane

Key Points

Implication

Discussion

Cite This Study

Catalytic Aerobic Sulfonyloximation of Alkenes Enabled by the Nitric Oxide-Donor Role of 2-Nitropropane

Key Points

Implication

Discussion

Cite This Study

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