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June 1, 2026Case Reports in RheumatologyOpen Access

A Case of Neural Tube Defect in Early Pregnancy Following Sulfasalazine Exposure Without Folic Acid Supplementation

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Authors

FHFrancesca HoldenRHRodney Hughes

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Overview

Case presentation uncovers neural tube defect in pregnancy after sulfasalazine exposure, highlighting supplementation importance.

Key Points

  • This case aims to illustrate the potential risks associated with sulfasalazine use during pregnancy without folic acid supplementation.
  • Case presentation of a woman with fetal anomalies after starting sulfasalazine without folic acid.
  • Evaluation of serum folate levels prior to conception and during pregnancy.
  • Assessment of other potential teratogenic exposures.
  • Fetal spina bifida and ventriculomegaly were diagnosed at 20 weeks' gestation leading to pregnancy termination.
  • The patient had borderline-low serum folate levels at conception (3.7 μg/L).
  • No other teratogenic exposures were identified, supporting the link to sulfasalazine.

Cite This Study

Holden et al. (2026) studied this question.

synapsesocial.com/papers/6a1d224302fbce91306380f0https://doi.org/10.1155/crrh/8352167
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