Why the study?
Observational studies show associations of insulin resistance and glycemic levels with adverse ventricular structure and function, but whether these associations are causal remains unclear.
Does genetic liability to insulin resistance and glycemic traits affect left ventricular structure and function?
Population
16,923 UK Biobank Cardiovascular Magnetic Resonance sub-study participants and up to 188,577 GWAS individuals of European ancestry
Comparison
Genetically predicted insulin resistance, fasting insulin, HbA1c, and fasting glucose
Design
Mendelian randomization study
Authors
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IR genetic liability may drive adverse LV remodeling; leaves open whether targeting IR improves HF outcomes.
Does genetic liability to insulin resistance and glycemic traits affect left ventricular structure and function?
Genetic liability to insulin resistance, but not glycemic levels, is causally associated with adverse changes in left ventricular structure and function, highlighting IR as a direct risk factor for heart failure.
Ai et al. (2022) studied this question.
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