What question did this study set out to answer?

This research aims to investigate the prevalence of knockdown resistance mutations and their role in pyrethroid susceptibility in Anopheles gambiae populations.

June 1, 2026BMC Research NotesOpen Access

Pyrethroid-resistance in Anopheles gambiae s.l (Culicidae) populations from the Sudan Savannah ecoregion in Nigeria is partly mediated by knockdown mutation

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Authors

OIOluyinka A. IyiolaUniversity of Ilorin AOAhmed Idowu OmotayoNigerian Institute of Medical Research OAOlukayode James AdelajaUniversity of Ilorin

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Implication

Randomized trial investigates pyrethroid resistance in Anopheles gambiae populations, highlighting the need for strategic vector control interventions.

Key Points

This research aims to investigate the prevalence of knockdown resistance mutations and their role in pyrethroid susceptibility in Anopheles gambiae populations.
Collected 250 An. gambiae mosquitoes from three Local Government Areas in Kwara State, Nigeria.
Performed molecular analysis to identify species and assess pyrethroid susceptibility.
Conducted kdr genotyping to determine mutation prevalence and resistance patterns.
Identified An. coluzzii (31.2%), An. gambiae s.s. (16.8%), and An. arabiensis (13.6%) with 38.4% failed amplification.
All populations showed resistance to permethrin, deltamethrin, and alphacypermethrin (mortality < 90%), with rates between 23% to 64%.
Found 41.6% homozygous resistant and 58.4% homozygous susceptible mosquitoes, with no heterozygotes detected, indicating strong selection pressure.

Cite This Study

Iyiola et al. (2026) studied this question.

synapsesocial.com/papers/6a1d228d02fbce9130638531 https://doi.org/10.1186/s13104-026-07877-5

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Implication

Randomized trial investigates pyrethroid resistance in Anopheles gambiae populations, highlighting the need for strategic vector control interventions.

Pyrethroid-resistance in Anopheles gambiae s.l (Culicidae) populations from the Sudan Savannah ecoregion in Nigeria is partly mediated by knockdown mutation

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Cite This Study

Pyrethroid-resistance in Anopheles gambiae s.l (Culicidae) populations from the Sudan Savannah ecoregion in Nigeria is partly mediated by knockdown mutation

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