Why the study?
Does the creation of transmural channels from the ventricular cavity improve blood supply to infarcted myocardium in a dog model?
Does the creation of transmural channels from the ventricular cavity improve blood supply to infarcted myocardium in a dog model?
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Creating 4-mm transmural channels from the left ventricle significantly increases blood supply to acutely infarcted myocardium in a canine model.
Direct communications between the left ventricular lumen and the myocardial sinusoids were produced by multiple myocardial punctures on 18 dogs of 3 different groups with ligation of coronary arteries. Blood flow was estimated in normal and punctured myocardium by measuring uptake of 86Rb. Results obtained in acute studies indicate: (1) no increase in blood flow to the infarcted myocardium using a cannula of 1.2 and 1.4 mm size; (2) a significant increase of 86Rb uptake and, therefore, of blood supply from the ventricular cavity when multiple 4-mm channels were made from the inside of the left ventricle.
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Walter et al. (2008) studied this question.
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