Key result
Closed-chest Ivalon plug technique successfully induces experimental MI in 9 dogs without immediate fatality.
Why the study?
Existing techniques for producing myocardial infarction in closed-chest animals were limited by catheter size, allowing only small branch occlusion and resulting in high mortality.
A novel catheter-based technique using a polyvinyl alcohol plug successfully and safely produced experimental myocardial infarction in a closed-chest dog model.
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Enables safer closed-chest canine MI models for research; leaves open translation to other species or clinical use.
Zollikofer et al. (1981) studied Experimental myocardial infarction (n=9). Ivalon (polyvinyl alcohol) plug occlusion was evaluated on Successful production of myocardial infarction with no immediate fatality. A new closed-chest technique using an Ivalon plug successfully produced experimental myocardial infarction in 9 dogs with no immediate fatality.
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