What does this research mean for the field?

Hydrogen peroxide is generated intracellularly during platelet activation and enhances platelet aggregation induced by soluble and particulate stimuli. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 3, 1985FEBS LettersOpen Access

Hydrogen peroxide has a role in the aggregation of human platelets

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Why the study?

What is the role of hydrogen peroxide in the aggregation of human platelets?

Population

Human platelets

Comparison

Addition of hydrogen peroxide, catalase, or… vs Control (no addition)

Design

Preclinical

Authors

DPDomenico Del PrincipeIstituto di Farmacologia Traslazionale AMAdriana MenichelliUniversity of Rome Tor Vergata WMWalter De MatteisUniversity of Rome Tor Vergata

Discussion

Member takes

Implication

H2O2 may enhance platelet aggregation in animal models; leaves open its role in human thrombosis and requires clinical validation.

Structured PICO

What is the role of hydrogen peroxide in the aggregation of human platelets?

Population

Human platelets

Intervention

Addition of hydrogen peroxide (H2O2), catalase, or aminotriazole

Comparator

Control (no addition)

Outcome

Platelet aggregationsurrogate

Hydrogen peroxide is formed intracellularly during platelet activation and plays a role in enhancing platelet aggregation.

Cite This Study

Principe et al. (1985) studied this question.

synapsesocial.com/papers/6a1d261b28423f2ce504d378 https://doi.org/10.1016/0014-5793(85)80758-4

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Hydrogen peroxide has a role in the aggregation of human platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hydrogen peroxide has a role in the aggregation of human platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider