Key result
Collagen-induced platelet aggregation is associated with a burst of H2O2 that acts as a second messenger by stimulating arachidonic acid metabolism and the phospholipase C pathway.
This study demonstrates that hydrogen peroxide acts as a second messenger in collagen-induced platelet activation, stimulating arachidonic acid metabolism and the phospholipase C pathway.
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May implicate H2O2 in collagen-specific platelet activation; hypothesis-generating for oxidative pathways in thrombosis.
Pignatelli et al. (1998) studied Platelet activation. Collagen and Catalase was evaluated on Platelet aggregation, H2O2 production, and pathway activation. Collagen-induced platelet aggregation is associated with a burst of H2O2 that acts as a second messenger by stimulating arachidonic acid metabolism and the phospholipase C pathway.
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