Pharmacological strategies to prevent haemodynamic changes after intubation in parturient women with hypertensive disorders of pregnancy: A network meta-analysis

Figures

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  Figure 1. PRISMA flowchart of trial inclusion and exclusion.

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  Figure 2. Network plot of the included studies comparing different pharmacological strategies. The nodes represent the pharmacological regimens used to prevent haemodynamic changes after intubation in parturient women with hypertensive disorders of pregnancy, and the edges show the available direct comparisons among them. Nodes and edges are weighted on the basis of the number of patients included and the inverse standard error of the effect. A) maximal mean arterial pressure, B) maximal systolic arterial pressure, C) maximal diastolic arterial pressure, D) maximal heart rate. Alf, alfentanil; Con, control; Fen, fentanyl; Hyd, hydralazine; Lab, labetalol; Nif, nifedipine; NTG, nitroglycerin; RemH, high dose of remifentanil; RemL, low dose of remifentanil.

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  Figure 3. Confidence interval plots between each management modality and the placebo group. The diamond shape represents the mean summary effects; the black line, 95% CI. A) maximal mean arterial pressure, B) maximal systolic arterial pressure, C) maximal diastolic arterial pressure, D) maximal heart rate. CI, confidence interval; Alf, alfentanil; Con, control; Fen, fentanyl; Hyd, hydralazine; Lab, labetalol; Nif, nifedipine; NTG, nitroglycerin; RemH, high dose of remifentanil; RemL, low dose of remifentanil.

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  Figure 4. Expected mean ranking and surface under the cumulative ranking curve (SUCRA) values. The X-axis represents the expected mean ranking based on the SUCRA value, and the Y-axis represents the SUCRA value. A) maximal mean arterial pressure, B) maximal systolic arterial pressure, C) maximal diastolic arterial pressure, D) maximal heart rate, E) Apgar score at 1 min, and F) Apgar score at 5 min. Alf, alfentanil; Con, control; Fen, fentanyl; Hyd, hydralazine; Lab, labetalol; Nif, nifedipine; NTG, nitroglycerin; RemH, high dose of remifentanil; RemL, low dose of remifentanil.