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July 1, 1990Blood

Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study

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Authors

WCWM CristUniversity of MinnesotaACAJ CarrollChildren's Hospital at WestmeadJSJJ ShusterUniversity of Florida

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Implication

Cohort study reveals worse treatment outcomes from t(1;19) translocation in childhood pre-B acute lymphoblastic leukemia, highlighting the need for risk-directed therapy.

Key Points

  • To assess the prognostic significance of chromosomal translocations, particularly t(1;19)(q23;p13), in children with pre-B and early pre-B acute lymphoblastic leukemia.
  • Evaluated bone marrow cytogenetics in children with pre-B (N=285) and early pre-B (N=679) acute lymphoblastic leukemia enrolled on a Pediatric Oncology Group risk-based protocol between February 1986 and May 1989.
  • Analyzed treatment failure rates across cytogenetic subgroups while adjusting for leukocyte count, age, and other clinical covariates.
  • Translocations of any kind were associated with worse outcomes than other karyotypic defects in pre-B (15 of 66 vs 3 of 64 failed, P = .001) and early pre-B leukemia (37 of 141 vs 23 of 239 failed, P < .001).
  • Among pre-B cases, patients with t(1;19) had significantly worse outcomes than all other patients (11 of 29 vs 27 of 256 failed, P < .001), remaining significant after adjustment for age and leukocyte count.
  • Pre-B patients with t(1;19) also experienced higher failure rates than pre-B patients with other translocations (11 of 29 vs 4 of 37 failed, P < .01) or other karyotypic abnormalities (11 of 29 vs 7 of 101 failed, P < .001).

Cite This Study

Crist et al. (1990) studied this question.

synapsesocial.com/papers/6a1d29bb5b7fddc35204ea09https://doi.org/10.1182/blood.v76.1.117.117
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Also Consider

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  1. 1Cytogenetic features and serum lactic dehydrogenase level predict a poor treatment outcome for children with pre-B-cell leukemia1986 · 54 citations
  2. 2The Morphological Classification of Acute Lymphoblastic Leukaemia: Concordance among Observers and Clinical Correlations1981 · 493 citations
  3. 3Immunofluorescent studies of the development of pre‐B cells, B lymphocytes and immunoglobulin isotype diversity in humans1977 · 487 citations
  4. 4Pre-B cell leukemia responds poorly to treatment: a pediatric oncology group study1984 · 9 citations
  5. 5Pre-B cell leukemia associated with chromosome translocation 1;191984 · 29 citations