High Life’s Essential 8 score is associated with lower aortic valve calcification

AIMS: This study aims to explore the relationship between Life's Essential 8 (LE8) and aortic valve calcification (AVC). METHODS AND RESULTS: The study included 30 561 participants from the Kailuan cohort who completed the Kailuan Health examination and underwent contemporaneous ultrasound assessment. A multifactorial logistic regression analysis was used to assess the relationship between LE8 score and AVC, along with subgroup analyses and an analysis of the impact of each component of LE8 on AVC. Among the 30 561 participants, 3717 (12.16%) cases of AVC were detected, with a detection rate of 12.16%. The detection rate of AVC significantly decreased with increased LE8 score (P < 0.001). The presence of AVC was reduced by 34% in the moderate cardiovascular health (CVH) group [odds ratio (OR) = 0.66, 95% confidence interval (CI) 0.60-0.72] and by 63% in the high CVH group (OR = 0.37, 95% CI 0.27-0.50). For each standard deviation increase in the LE8 score, the presence of AVC decreased by 23% (OR = 0.77, 95% CI 0.74-0.80). Analysis of the individual components of LE8 revealed that diet, exercise, body mass index, blood lipids, blood glucose, and blood pressure were all associated with the reduced presence of AVC. In contrast, no impact of sleep and smoking on AVC presence was observed. CONCLUSION: The study indicates that a higher LE8 score was associated with lower the presence of AVC.