What question did this study set out to answer?

To assess the frequency and duration of persistent respiratory infection with Chlamydia pneumoniae following an acute respiratory illness.

January 1, 1992Clinical Infectious Diseases

Persistent Infection with Chlamydia pneumoniae following Acute Respiratory Illness

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Authors

MHMargaret R. HammerschlagSUNY Downstate Health Sciences University KCK ChirgwinState University of New York PRP M RoblinSUNY Downstate Health Sciences University

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Implication

Observational study reveals persistent Chlamydia pneumoniae carriage in respiratory patients, suggesting standard antibiotic courses may fail to eradicate the bacteria.

Key Points

To assess the frequency and duration of persistent respiratory infection with Chlamydia pneumoniae following an acute respiratory illness.
Followed 9 individuals with culture-confirmed C. pneumoniae respiratory illness to obtain repeat respiratory cultures over up to 1 year.
Assessed acute serologic response via IgM antibody titers (defined as titers ≥1:16) and tracked clinical responses to tetracycline or doxycycline therapy.
Persistent infection was documented in 5 of 9 individuals (55.6%), consisting of 4 patients with pharyngitis and 1 with bronchitis accompanied by prominent bronchospasm.
All 5 patients with persistent infection demonstrated IgM antibody titers ≥1:16, indicating acute infection.
Cultures remained positive for 11 months in 3 patients despite completion of 10- to 21-day antibiotic courses of tetracycline or doxycycline.

Cite This Study

Hammerschlag et al. (1992) studied this question.

synapsesocial.com/papers/6a1d30371e7099f6910507a1 https://doi.org/10.1093/clinids/14.1.178

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Implication

Observational study reveals persistent Chlamydia pneumoniae carriage in respiratory patients, suggesting standard antibiotic courses may fail to eradicate the bacteria.

Persistent Infection with Chlamydia pneumoniae following Acute Respiratory Illness

Discussion

Member takes

Implication

Key Points

Cite This Study

Persistent Infection with Chlamydia pneumoniae following Acute Respiratory Illness

Discussion

Member takes

Implication

Key Points

Cite This Study

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