What does this research mean for the field?

Specific highly conserved T-cell epitopes within the foot-and-mouth disease virus (FMDV) nonstructural proteins 3A, 3B, and 3C elicit strong MHC-restricted responses, and combining the 3A T-cell epitope with a B-cell antigenic site induces T helper activity that cooperatively stimulates anti-FMDV antibody production. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 2001Journal of VirologyOpen Access

Identification of T-Cell Epitopes in Nonstructural Proteins of Foot-and-Mouth Disease Virus

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Population

Lymphocytes obtained from outbred pigs experimentally infected with foot-and-mouth disease virus (FMDV)

Design

Preclinical

Authors

EBEsther BlancoCentro Regional de Selección y Reproducción Animal MGMercedes García-BrionesInstituto de Biotecnología de León ASArantza Sanz-ParraCIC bioGUNE

Discussion

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Implication

Tandem 3A-VP1 peptides merit vaccine testing in livestock; leaves open translation beyond this animal model.

Structured PICO

Population

Lymphocytes obtained from outbred pigs experimentally infected with foot-and-mouth disease virus (FMDV)

Intervention

In vitro stimulation with FMDV nonstructural proteins (NSP) including polypeptides 3A, 3B, and 3C, overlapping synthetic peptides, and a tandem peptide containing T-cell peptide 3A[21-35] and B-cell antigenic site VP1[137-156]

Outcome

In vitro lymphoproliferative responses and induction of serotype-specific antiviral activitysurrogate

Inclusion of a T-cell epitope derived from the FMDV nonstructural protein 3A can induce T helper activity, allowing cooperative induction of anti-FMDV antibodies by B cells.

Cite This Study

Blanco et al. (2001) studied this question.

synapsesocial.com/papers/6a1d36cf750575be8d2f4a78 https://doi.org/10.1128/jvi.75.7.3164-3174.2001

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Identification of T-Cell Epitopes in Nonstructural Proteins of Foot-and-Mouth Disease Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of T-Cell Epitopes in Nonstructural Proteins of Foot-and-Mouth Disease Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider