Population
Cardiac fibroblasts and cardiomyocytes
Comparison
PAR-1 activation by thrombin vs Other G protein-coupled receptor agonists
Design
Preclinical
Authors
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Hypothesis-generating for PAR-1 in cardiac remodeling; leaves open in vivo relevance and therapeutic translation.
PAR-1 activation by thrombin drives DNA synthesis in cardiac fibroblasts via EGFR transactivation, providing a potential mechanism for cardiac remodeling during injury or inflammation.
Sabri et al. (2002) studied this question.
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