Why the study?
Does a hypotensive drug combination including beta-blockers reduce mortality and cardiovascular complications compared to a combination including diuretics in hypertensive patients with LVH?
Population
304 hypertensive patients with different degrees of left ventricular hypertrophy (LVH)
Comparison
Combination of hypotensive drugs including… vs Combination of hypotensive drugs including…
Design
RCT, Randomized into two groups
Follow-up
4 years
Authors
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Beta-blocker-based regimens may be preferred over diuretic-based in hypertensive LVH; supports consensus on beta-blocker mortality benefit.
Does a hypotensive drug combination including beta-blockers reduce mortality and cardiovascular complications compared to a combination including diuretics in hypertensive patients with LVH?
In hypertensive patients with LVH, a beta-blocker-based antihypertensive regimen significantly reduced mortality compared to a diuretic-based regimen over 4 years.
Yurenev et al. (1992) studied this question.
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