Why the study?
Does atenolol improve left ventricular dimensions and systolic function compared to hydrochlorothiazide and amiloride in mildly hypertensive men?
Does atenolol improve left ventricular dimensions and systolic function compared to hydrochlorothiazide and amiloride in mildly hypertensive men?
Atenolol and hydrochlorothiazide/amiloride both reduce left ventricular mass in mildly hypertensive men, but have differing effects on left ventricular wall thickness and stroke volume.
Differential effects on wall thickness and stroke volume may guide therapy selection in mild hypertension; extends evidence on drug-specific LV remodeling.
In a randomized double-blind study to compare the effect of atenolol vs. hydrochlorothiazide and amiloride (Moduretic) on left ventricular dimensions and systolic function, 100 hypertensive men were followed up during 1 year of treatment, 50 subjects being randomized to each drug. Echocardiography was performed at baseline, and after 3 and 12 months of treatment. A significant reduction in left ventricular mass with atenolol was paralleled by a decrease in left ventricular wall thickness and an increase in stroke volume. A similar reduction of left ventricular mass with Moduretic without a change in relative wall thickness and a decrease in stroke volume was observed. Cardiac output decreased in both groups.
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Otterstad et al. (1992) studied this question.
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