What does this research mean for the field?

Fetal and neonatal myocardium express unique fetal titin isoforms with additional spring elements, resulting in passive myocardium that is less stiff in neonates than in adults. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

This study aims to understand how titin isoform expression changes during heart development in different species.

January 6, 2004Circulation ResearchOpen Access

Developmental Control of Titin Isoform Expression and Passive Stiffness in Fetal and Neonatal Myocardium

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Population

Fetal and neonatal myocardium from a range of species

Comparison

Developmental stage (fetal/neonatal) vs Adult myocardium

Design

Preclinical

Authors

SLSunshine LahmersVirginia–Maryland College of Veterinary Medicine YWYiming WuShanghai Mental Health Center DCDouglas R. CallWashington State University

Discussion

Member takes

Implication

Challenges prior reports of stiffer neonatal myocardium; leaves open titin isoform effects on human diastolic development.

Key Points

This study aims to understand how titin isoform expression changes during heart development in different species.
Evaluated titin isoform expression using a novel titin exon microarray covering all 363 exons.
Assessed contractile behavior in fetal and neonatal myocardium across a range of species.
Monitored alterations in passive stiffness relative to age.
Fetal titin isoforms characterized by additional spring elements predominate in fetal and neonatal myocardium.
Neonatal myocardium shows less passive stiffness compared to adults, contrary to previous findings.
Changes in titin expression are linked to functional transitions in heart development.

Structured PICO

Population

Fetal and neonatal myocardium from a range of species

Intervention

Developmental stage (fetal/neonatal)

Comparator

Adult myocardium

Outcome

Titin isoform expression and passive stiffnesssurrogate

Fetal and neonatal myocardium express unique titin isoforms that make the heart less stiff, impacting diastolic filling behavior during development.

Cite This Study

Lahmers et al. (2004) studied this question.

synapsesocial.com/papers/6a1d41bb33e2df9c962f3476 https://doi.org/10.1161/01.res.0000115522.52554.86

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Developmental Control of Titin Isoform Expression and Passive Stiffness in Fetal and Neonatal Myocardium

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Developmental Control of Titin Isoform Expression and Passive Stiffness in Fetal and Neonatal Myocardium

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider