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September 10, 2002CirculationOpen Access

Changes in Titin Isoform Expression in Pacing-Induced Cardiac Failure Give Rise to Increased Passive Muscle Stiffness

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Population

Canine pacing-induced heart failure model

Design

Preclinical

Authors

YWYiming WuShanghai Mental Health CenterSBStephen P. BellHoward Hughes Medical InstituteKTK TrombitásHeart Failure / Cardiomyopathy

Discussion

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Implication

Titin isoform shifts increase stiffness in this canine HF model; hypothesis-generating for diastolic dysfunction mechanisms, with no clinical implications yet.

Structured PICO

P
Population
Canine pacing-induced heart failure model
I
Intervention
Pacing-induced heart failure
O
Outcome
Changes in titin isoform expression and passive muscle stiffnesssurrogate

Changes in titin isoform expression ratios increase myocardial passive stiffness, suggesting a molecular mechanism for diastolic dysfunction in heart failure.

Cite This Study

Wu et al. (2002) studied this question.

synapsesocial.com/papers/69d573f8cb7e4bf698cf4051https://doi.org/10.1161/01.cir.0000029804.61510.02
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fibrillar collagen and remodeling of dilated canine left ventricle.1990 · 263 citations
  2. 2Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently2001 · 89 citations
  3. 3Cardiac titin: an adjustable multi‐functional spring2002 · 232 citations
  4. 4Alterations in the Determinants of Diastolic Suction During Pacing Tachycardia2000 · 191 citations
  5. 5Series of Exon-Skipping Events in the Elastic Spring Region of Titin as the Structural Basis for Myofibrillar Elastic Diversity2000 · 393 citations