July 7, 2004Circulation
Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy
Population
26 subjects: 20 patients with end-stage heart failure resulting from nonischemic dilated cardiomyopathy and…
Design
Case-control
Authors
Discussion
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Member takes
Implication
Titin isoform shift may contribute to diastolic changes in HF; hypothesis-generating and requires prospective validation before any clinical consideration.
Structured PICO
P
Population
26 subjects: 20 patients with end-stage heart failure resulting from nonischemic dilated cardiomyopathy and 6 controls.
C
Comparator
6 controls
O
Outcome
Titin isoform expression (N2BA:N2B ratio) and passive muscle stiffnesssurrogate
In end-stage nonischemic dilated cardiomyopathy, an increased ratio of compliant (N2BA) to stiff (N2B) titin isoforms lowers myocardial stiffness and impacts diastolic filling.
Cite This Study
Nagueh et al. (2004) studied this question.