Key result
Chronically ischemic human hearts exhibited a titin isoform switch with an increased N2BA-to-N2B ratio (47:53 vs 32:68 in nonischemic hearts), causing reduced titin-derived myofibrillar stiffness.
Authors
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Titin isoform switch may contribute to diastolic dysfunction in chronic ischemia; extends mechanistic insights to human myocardium.
Observational
Absolute Event Rate: 47% vs 32%
Neagoe et al. (2002) conducted an observational in Ischemic heart disease / Coronary artery disease. Coronary artery disease (ischemia) vs. Nonischemic hearts was evaluated on N2BA-to-N2B titin isoform ratio. Chronically ischemic human hearts exhibited a titin isoform switch with an increased N2BA-to-N2B ratio (47:53 vs 32:68 in nonischemic hearts), causing reduced titin-derived myofibrillar stiffness.
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