What question did this study set out to answer?

To compare measured glomerular filtration rate using technetium-99m DTPA renal scintigraphy with estimated glomerular filtration rate calculated from 24-hour creatinine clearance, Cockcroft-Gault, and Modification of Diet in Renal Disease formulas in hypertensive patients with normal serum creatinine.

March 25, 2010Blood PressureOpen Access

Comparison of methods for determination of glomerular filtration rate in hypertensive subjects with normal serum creatinine

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Authors

AMAlberto MazzaAdrian College DMDomenico MontemurroUniversity of Padua APAntonio PiccoliUniversidade Federal do Rio Grande do Sul

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Implication

Comparative study shows 24-hour creatinine clearance outperforms estimation formulas in hypertensive patients with normal serum creatinine, highlighting hidden renal impairment.

Key Points

To compare measured glomerular filtration rate using technetium-99m DTPA renal scintigraphy with estimated glomerular filtration rate calculated from 24-hour creatinine clearance, Cockcroft-Gault, and Modification of Diet in Renal Disease formulas in hypertensive patients with normal serum creatinine.
Evaluated N=200 normoalbuminuric hypertensive patients aged 55–75 years with normal serum creatinine and no history of diabetes, coronary disease, or cerebrovascular disease.
Assessed agreement between scintigraphic GFR and estimated GFR formulas using Pearson's correlation and Bland-Altman bias spans across normal (≥60 ml/min/1.73 m²) and low (<60 ml/min/1.73 m²) filtration subgroups.
Technetium-99m DTPA renal scintigraphy identified previously undetected renal impairment (<60 ml/min/1.73 m²) in 38% of subjects (n=76).
Bland-Altman analysis demonstrated that 24-hour creatinine clearance had the narrowest limits of agreement span with scintigraphy in both normal (26.0 ml/min/1.73 m²) and low renal function cohorts (21.2 ml/min/1.73 m²), whereas Cockcroft-Gault (41.0 and 30.4 ml/min/1.73 m²) and Modification of Diet in Renal Disease formulas (40.4 and 31.8 ml/min/1.73 m²) showed substantially wider variation.

Cite This Study

Mazza et al. (2010) studied this question.

synapsesocial.com/papers/6a1d44005a0c5c56ea04d18b https://doi.org/10.3109/08037051003718473

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Implication

Comparative study shows 24-hour creatinine clearance outperforms estimation formulas in hypertensive patients with normal serum creatinine, highlighting hidden renal impairment.

Comparison of methods for determination of glomerular filtration rate in hypertensive subjects with normal serum creatinine

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of methods for determination of glomerular filtration rate in hypertensive subjects with normal serum creatinine

Discussion

Member takes

Implication

Key Points

Cite This Study

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