What does this research mean for the field?

In cirrhosis, Atrial Natriuretic Factor (ANF) primarily acts to maintain sodium homeostasis during the early compensated stage, but it has no primary role in sodium retention and becomes ineffective in late ascitic cirrhosis due to the development of renal resistance. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1993HepatologyOpen Access

Atrial Natriuretic Factor and Liver Disease

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Population

Patients with cirrhosis

Design

Review

Authors

LWLeonard C. WarnerAlbany State University KSKarl SkoreckiBar-Ilan University LBLaurence M. BlendisBoston University

Discussion

Member takes

Implication

ANF modulation should not guide sodium management in ascitic cirrhosis; leaves open its stage-specific role for prospective validation.

Structured PICO

Population

Patients with cirrhosis

This review proposes that while ANF helps maintain sodium homeostasis in early cirrhosis, renal resistance renders it ineffective in late stages, and it may even contribute to edema formation.

Cite This Study

Warner et al. (1993) studied this question.

synapsesocial.com/papers/6a1d445b750575be8d2f576a https://doi.org/10.1002/hep.1840170322

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Atrial Natriuretic Factor and Liver Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Atrial Natriuretic Factor and Liver Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider