Why the study?
Does intravenous sodium lactate cause ventricular arrhythmias in patients with heart block?
Does intravenous sodium lactate cause ventricular arrhythmias in patients with heart block?
Intravenous sodium lactate is hazardous in patients with heart block due to a high risk of inducing ventricular tachycardia, whereas isopropylnorepinephrine is safer and more effective.
Answers are grounded in this paper and cite their sources.
May provoke VT in heart block; challenges prior safety reports but remains hypothesis-generating.
Molar sodium lactate has been described as a safe and effective agent in the treatment of bradycardia accompanying complete heart block. However, in 12 patients with heart block, hypertonic lactate infusions produced ventricular tachycardia in 6 and an increased idioventricular rate in only 4. Isopropylnorepinephrine was more effective and without such hazard. The effects of alkalosis from molar lactate, 5 per cent sodium bicarbonate, and hyperventilation are compared. Of these 3, lactate was productive of the greatest ventricular acceleration.
No takes yet. Share an insight, caveat, or question.
Murray et al. (1957) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: