A long-term normothermic machine perfusion platform is being developed for repairing and regenerating damaged livers to make them suitable for transplantation. The energy expenditure and the metabolic needs of 14 human donor livers were observed during NMP for up to a week. We noticed that livers become metabolically quiescent after 3 days and that a change in our nutrimental support protocol might be necessary to provide a better environment for the livers during NMP.
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Lascaris et al. (2025) studied this question.
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