Key result
Acute right ventricular apical pacing significantly increased maximal left atrial volume compared to intrinsic conduction (55.2 vs 52.0 mL, P=0.005) and impaired atrial contractility.
Why the study?
Does acute right ventricular apical pacing impair left atrial function and induce remodeling compared to intrinsic ventricular conduction in patients with normal ejection fraction?
Population
94 patients with implanted right ventricular apical-based dual-chamber pacemakers and normal ejection…
Comparison
Right ventricular apical pacing for 15 minutes vs Intrinsic ventricular conduction (V-sense)
Design
Cross-sectional
Follow-up
15 minutes (acute assessment)
Authors
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Suggests acute LA impairment with RV apical pacing; hypothesis-generating for chronic remodeling risk in normal-EF patients.
Observational (n=94)
Does acute right ventricular apical pacing impair left atrial function and induce remodeling compared to intrinsic ventricular conduction in patients with normal ejection fraction?
Absolute Event Rate: 55.2% vs 52%
p-value: p=0.005
Acute right ventricular apical pacing induces immediate left atrial enlargement and impairs atrial contractility, particularly in patients with preexisting diastolic dysfunction.
Xie et al. (2012) conducted an observational in Patients with implanted RVA-based dual-chamber pacemakers (n=94). Right ventricular apical (RVA) pacing (V-pace) vs. Intrinsic ventricular conduction (V-sense) was evaluated on Total maximal LA volume (LAVmax) (p=0.005). Acute right ventricular apical pacing significantly increased maximal left atrial volume compared to intrinsic conduction (55.2 vs 52.0 mL, P=0.005) and impaired atrial contractility.
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