Key result
RVA pacing linked to ~43% greater LV dyssynchrony and reduced LVEF vs sinus rhythm.
Why the study?
Does right ventricular apical pacing alter left ventricular function and mechanical dyssynchrony compared to intrinsic sinus rhythm in patients with implanted cardiac devices?
Population
26 patients with implanted cardiac devices and normal intrinsic atrioventricular conduction
Comparison
Right ventricular apical (RVA) pacing vs Intrinsic sinus rhythm
Design
Cross-sectional
Follow-up
acute
Authors
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Acute RVA pacing effects on 3D LV function remain incompletely defined; leaves open link to long-term HF risk.
Cross-Sectional (n=26)
Does right ventricular apical pacing alter left ventricular function and mechanical dyssynchrony compared to intrinsic sinus rhythm in patients with implanted cardiac devices?
Absolute Event Rate: 6.3% vs 4.4%
p-value: p=0.001
Right ventricular apical pacing acutely induces left ventricular dyssynchrony and reduces ejection fraction compared to intrinsic sinus rhythm, as demonstrated by real-time 3D echocardiography.
Wölber et al. (2010) conducted a cross-sectional in Implanted cardiac devices with normal intrinsic atrioventricular conduction (n=26). Right ventricular apical (RVA) pacing vs. Intrinsic sinus rhythm was evaluated on Left ventricular (LV) dyssynchrony (systolic dyssynchrony index) (p=0.001). Right ventricular apical pacing acutely increased left ventricular dyssynchrony (SDI 6.3% vs 4.4%, P=0.001) and reduced ejection fraction (47% vs 53%, P=0.05) compared to intrinsic sinus rhythm.
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