September 1, 2008European Journal of Gastroenterology & Hepatology

Validity of N-terminal propeptide of the brain natriuretic peptide in predicting left ventricular diastolic dysfunction diagnosed by tissue Doppler imaging in patients with chronic liver disease

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Why the study?

Does NT-proBNP accurately predict left ventricular diastolic dysfunction diagnosed by tissue Doppler imaging in patients with chronic liver disease?

Population

64 patients with chronic liver disease

Comparison

Serum NT-proBNP measurement vs Tissue Doppler imaging

Design

Cross-sectional

Authors

TRTanja Raedle-HurstSaarland University CWChristoph WelschGoethe University Frankfurt NFNicole ForestierSchön Klinik Bad Aibling

Discussion

Member takes

Implication

May support NT-proBNP screening for advanced diastolic dysfunction in chronic liver disease; hypothesis-generating pending prospective validation.

Structured PICO

Does NT-proBNP accurately predict left ventricular diastolic dysfunction diagnosed by tissue Doppler imaging in patients with chronic liver disease?

Population

64 patients with chronic liver disease (31 with severe liver fibrosis/cirrhosis, 8 with moderate fibrosis, and 25 with mild fibrosis)

Intervention

Serum NT-proBNP measurement

Comparator

Tissue Doppler imaging (reference standard for diagnosing left ventricular diastolic dysfunction)

Outcome

Accuracy of NT-proBNP in predicting advanced left ventricular diastolic dysfunctionsurrogate

NT-proBNP >290 pg/ml is a highly accurate marker for detecting advanced left ventricular diastolic dysfunction in patients with chronic liver disease, identifying those who should undergo further cardiac evaluation.

Cite This Study

Raedle-Hurst et al. (2008) studied this question.

synapsesocial.com/papers/6a1d554ecc9f7df1b70544b3 https://doi.org/10.1097/meg.0b013e3282fb7cd0

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Implication

May support NT-proBNP screening for advanced diastolic dysfunction in chronic liver disease; hypothesis-generating pending prospective validation.

Validity of N-terminal propeptide of the brain natriuretic peptide in predicting left ventricular diastolic dysfunction diagnosed by tissue Doppler imaging in patients with chronic liver disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Validity of N-terminal propeptide of the brain natriuretic peptide in predicting left ventricular diastolic dysfunction diagnosed by tissue Doppler imaging in patients with chronic liver disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider