What does this research mean for the field?

An intrinsic, angiotensin I-converting enzyme-dependent angiotensin system exists in the cardiac sympathetic ganglia and is activated by high-frequency preganglionic stimulation to release angiotensin II and upregulate angiotensinogen mRNA. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 19, 2001Circulation ResearchOpen Access

Upregulation of Immunoreactive Angiotensin II Release and Angiotensinogen mRNA Expression by High-Frequency Preganglionic Stimulation at the Canine Cardiac Sympathetic Ganglia

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Population

Canine cardiac sympathetic ganglia (in vivo dogs and isolated ganglia)

Comparison

High-frequency preganglionic stellate stimulation vs Postganglionic stellate stimulation, intravenous…

Design

Preclinical

Follow-up

1 hour (for in vivo mRNA expression)

Authors

KKKazushi KushikuFukuoka University HYHiromi YamadaYasuda Women's University KSKazuhiko ShibataToin University of Yokohama

Discussion

Member takes

Implication

Hypothesis-generating for ganglionic angiotensin modulation; human studies required before any clinical relevance.

Structured PICO

Population

Canine cardiac sympathetic ganglia (in vivo dogs and isolated ganglia)

Intervention

High-frequency preganglionic stellate stimulation (with pharmacological interventions including forasartan, captopril, and chymostatin)

Comparator

Postganglionic stellate stimulation, intravenous norepinephrine, or baseline

Outcome

Positive chronotropic responses, levels of endogenous immunoreactive angiotensin II, and expression of angiotensinogen mRNAsurrogate

An intrinsic ACE-dependent angiotensin system exists in canine cardiac sympathetic ganglia and is activated by high-frequency preganglionic stimulation.

Cite This Study

Kushiku et al. (2001) studied this question.

synapsesocial.com/papers/6a1d55597328fa9a742f57ad https://doi.org/10.1161/01.res.88.1.110

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Upregulation of Immunoreactive Angiotensin II Release and Angiotensinogen mRNA Expression by High-Frequency Preganglionic Stimulation at the Canine Cardiac Sympathetic Ganglia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Upregulation of Immunoreactive Angiotensin II Release and Angiotensinogen mRNA Expression by High-Frequency Preganglionic Stimulation at the Canine Cardiac Sympathetic Ganglia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider