November 1, 1991AJP Regulatory Integrative and Comparative Physiology

Beta 1- and beta 2-adrenoceptor subtypes in canine intrathoracic efferent sympathetic nervous system regulating the heart

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Population

Canine model (acutely decentralized canine efferent preganglionic sympathetic axons)

Comparison

Administration of beta 1- or beta 2-selective… vs Before administration (baseline stimulation)

Design

Preclinical

Authors

WWWendy Watson-WrightDalhousie University GBGuy BoudreauCentre Hospitalier de l’Université de Montréal RCR. CardinalElectrophysiology

Discussion

Member takes

Implication

Beta1- and beta2-adrenoceptors modulate intrathoracic sympathetic control in canines; extends mechanistic models but leaves human translation open.

Structured PICO

Population

Canine model (acutely decentralized canine efferent preganglionic sympathetic axons)

Intervention

Administration of beta 1 (atenolol)- or beta 2 (ICI 118551)-selective adrenoceptor antagonists into the ipsilateral stellate and middle cervical ganglia

Comparator

Before administration (baseline stimulation)

Outcome

Augmentations of right and left ventricular inotropism induced by efferent preganglionic sympathetic axon stimulationsurrogate

Canine intrathoracic neurons contain both beta 1- and beta 2-adrenoceptors that are involved in the efferent sympathetic regulation of the heart.

Cite This Study

Watson-Wright et al. (1991) studied this question.

synapsesocial.com/papers/6a70cb0a5d37378ac1ddf25e https://doi.org/10.1152/ajpregu.1991.261.5.r1269

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Implication

Beta1- and beta2-adrenoceptors modulate intrathoracic sympathetic control in canines; extends mechanistic models but leaves human translation open.