Key result
The 10 most widely published cardiovascular blood biomarkers demonstrated limited or no predictive ability for cardiovascular disease.
Why the study?
Do the most popular blood biomarkers predict cardiovascular disease?
Do the most popular blood biomarkers predict cardiovascular disease?
The most widely studied cardiovascular blood biomarkers demonstrate minimal to no predictive utility for cardiovascular disease, suggesting a need to reevaluate biomarker qualification.
Questions routine clinical use of top biomarkers for CVD prediction; challenges their qualification and redirects research to superior markers.
At least 10 cardiovascular biomarkers that can be measured in blood have accrued more than 6000 published related papers each.A systematic evaluation of the evidence suggests that they have limited or no predictive ability for cardiovascular disease and suggests the need for a paradigm shift in testing and qualifying biomarkers and in the expectations surrounding them.
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Ioannidis et al. (2012) studied this question. The 10 most widely published cardiovascular blood biomarkers demonstrated limited or no predictive ability for cardiovascular disease.
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