Just mix in water 'n stir: Pd-catalyzed CH activation/cross-couplings can be carried out at room temperature in water/surfactant mixtures. The combination of Pd(OAc)2 and HBF4 allowed for reactions of aryl ureas with aryl iodides under very mild conditions, using micellar catalysis (see scheme). This reaction is made possible by use of an in situ generated cationic palladium catalyst.
No takes yet. Share an insight, caveat, or question.
Nishikata et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: