Key result
Worsening renal function develops in ~43% of acute heart failure admissions, mostly within 48 hours.
Why the study?
Worsening renal function in acute heart failure has multifactorial mechanisms and heterogeneous prognostic impacts, prompting this evaluation of its characteristics and renal kinetics.
Cohort (n=196)
No
Worsening renal function occurs in nearly half of acute heart failure admissions but is mostly mild and typically recovers by the time of hospital discharge.
WRF in acute HF is often early and recoverable; leaves open its prognostic value and management implications in larger cohorts.
AIMS: Worsening renal function (WRF) in acute heart failure (AHF) has multifactorial pathophysiological mechanisms and heterogeneous prognostic impacts. The aim of this study was to determine the characteristics and renal kinetics of this phenomenon. METHODS AND RESULTS: We prospectively enrolled a cohort of 196 patients admitted for AHF to the Cardiology Department at Nhan Dan Gia Dinh Hospital, from July 2016 to March 2017. AHF was defined using the 2012 European Society of Cardiology criteria. The definition and severity of WRF were based on the 2012 Kidney Disease Improving Outcome criteria for acute kidney injury. Renal recovery was classified using the 2017 Acute Disease Quality Initiative 16 Workgroup Consensus. Among the 196 patients studied, WRF developed in 43.4%. In 80.0% of patients, WRF occurred within 48 hours of admission. In the WRF group, 89.4% were at stage 1, consistent with a relative increase in median serum creatinine of 49.5%. A total of 76.5% of the patients with WRF recovered at discharge, while rapid recovery occurred in 20.0% of patients. CONCLUSIONS: Most cases of WRF were mild, and WRF was correlated with a high rate of recovery during hospitalisation. However, rapid renal recovery was not common.
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Giang et al. (2020) conducted a cohort in Acute heart failure (n=196). Worsening renal function (WRF) vs. No worsening renal function was evaluated on Incidence of worsening renal function (WRF) during hospitalization. Among patients admitted for acute heart failure, worsening renal function developed in 43.4%, with 80.0% of cases occurring within 48 hours of admission and 76.5% recovering by discharge.
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