Key result
The duration of type 2 diabetes mellitus demonstrated a significant positive correlation (r=0.5920) with the severity of cardiovascular autonomic neuropathy.
Why the study?
Cardiovascular autonomic neuropathy is a clinically important, life-threatening, and often overlooked complication of diabetes mellitus, prompting assessment of how its severity correlates with disease duration.
Cross-Sectional (n=120)
No
Effect estimate: r=0.5920
p-value: p=< 0.001
The severity of cardiovascular autonomic neuropathy significantly correlates with the duration of type 2 diabetes mellitus, suggesting that cardiovascular reflex evaluation should be routine in these patients.
Longer T2DM duration was associated with CAN severity; leaves open whether routine screening improves outcomes.
Introduction Cardiovascular Autonomic Neuropathy (CAN) is one of the most overlooked complications of DM and is clinically important because of its life threatening consequences. CAN results from damage to the autonomic nerve fibers that innervate the heart and blood vessels. Aims and Objectives The aim of the present study is to assess the correlation between severity of cardiovascular autonomic functions in type 2 DM and duration of diabetes. Method The study included 30 cases of type 2 diabetes mellitus without diabetic retinopathy and 30 cases of type 2 diabetes mellitus with non proliferative diabetic retinopathy (NPDR). 60 non diabetic healthy volunteers matched for age and gender were included in the study to serve as control. The study group was classified into 3 groups according to duration of diabetes. All the subjects performed five different autonomic function tests as given by Ewing's and Clarke. The score value was obtained from various tests and a scoring system was applied as recommended by Bellavere F et al (1983).4 The results obtained were analysed statistically by one-way ANOVA and intergroup comparisons were made using post hoc Tukey multiple comparison test. Results The observations suggest that cardiac autonomic function declines in type 2 diabetics and CAN is more in diabetic patients with associated retinopathy The observations revealed that number of patients with autonomic dysfunction was more when duration of DM was long (>7 years) (83.3% in group 1 and 81.2% in group 2). The number of patients with CAN increased with duration of DM. Correlation between disease duration and cardiovascular autonomic score indicates significant positive correlation (r=0.5920). Conclusion The cardiac autonomic functions were found to be altered significantly in diabetics. Diabetic patients with longer duration of diabetes showed more severe dysfunction of cardiovascular functions. Hence, Evaluation of cardiovascular reflexes should be included as a routine in the work-up of patients of Type 2 diabetes mellitus.
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Subodh Pandey Juhi Agrawal (2019) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=120). Type 2 Diabetes Mellitus vs. Healthy non-diabetic volunteers was evaluated on Correlation between duration of diabetes and cardiovascular autonomic function tests score (r=0.5920, p=< 0.001). The duration of type 2 diabetes mellitus demonstrated a significant positive correlation (r=0.5920) with the severity of cardiovascular autonomic neuropathy.
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