Key result
WASP family proteins act as signal-regulated molecular switches that initiate actin polymerization through activation of the Arp2/3 complex.
This review summarizes the molecular mechanisms by which WASP family proteins regulate actin cytoskeleton reorganization.
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Provides molecular insights into Wiskott-Aldrich syndrome; leaves open clinical translation of WASP-Arp2/3 modulation.
Hiroaki Miki (2003) conducted a review in Wiskott-Aldrich syndrome. WASP family proteins was evaluated. WASP family proteins act as signal-regulated molecular switches that initiate actin polymerization through activation of the Arp2/3 complex.
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