Key result
The proline-rich regions of WASP and Scar1 and the EVH1 domain of WASP independently enhanced actin-based motility rates by recruiting additional factors, including profilin.
The proline-rich regions of WASP and Scar1 and the EVH1 domain of WASP stimulate cellular actin-based motility by recruiting factors such as profilin.
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May inform cytoskeletal studies in cardiovascular cells; leaves open relevance to human cardiac function or disease.
Yarar et al. (2002) studied this question. WASP and Scar1 truncation derivatives vs. Full-length WASP/Scar1 or control extracts was evaluated on Bead motility rate (µm/min). The proline-rich regions of WASP and Scar1 and the EVH1 domain of WASP independently enhanced actin-based motility rates by recruiting additional factors, including profilin.
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