Key result
Dimethyl fumarate pretreatment significantly reduced doxorubicin-induced DNA damage, micronucleus appearance, and chromosomal aberrations while restoring antioxidant enzyme activity in rats.
Why the study?
Doxorubicin has clinical utility limited by genotoxic and cytotoxic effects, prompting investigation into the protective effects of dimethyl fumarate against doxorubicin-induced chromosomal and DNA damage.
Does dimethyl fumarate prevent doxorubicin-induced chromosomal and DNA damage in Wistar Albino rats?
Population
Wistar Albino rats of both sexes
Comparison
Oral DMF alone or with a single dose of doxorubicin vs controls
Design
Animal experimental study
Follow-up
24 hours after doxorubicin injection
Authors
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DMF attenuates doxorubicin genotoxicity in rats; leaves open translation to human cardioprotection or practice change.
Does dimethyl fumarate prevent doxorubicin-induced chromosomal and DNA damage in Wistar Albino rats?
Dimethyl fumarate demonstrates protective effects against doxorubicin-induced genotoxicity and oxidative stress in a rat model.
kenany et al. (2023) studied Doxorubicin-induced genotoxicity. Dimethyl fumarate (DMF) vs. Doxorubicin-only and control group was evaluated on Chromosomal and DNA damage in rat bone marrow cells (MDA, GSH, SOD, GPx1, chromosomal aberration, micronucleus, and comet assays). Dimethyl fumarate pretreatment significantly reduced doxorubicin-induced DNA damage, micronucleus appearance, and chromosomal aberrations while restoring antioxidant enzyme activity in rats.
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