This review highlights the role of endothelin-1 in acute and chronic renal failure and discusses the potential therapeutic use of endothelin receptor antagonists.
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Endothelin antagonists merit targeted trials in renal failure; leaves open clinical efficacy pending randomized evidence.
The endothelin system has been implicated in various renal diseases. This review focuses on the involvement of endothelin-1 in pathogenesis and pathophysiology of acute and chronic renal failure with regard to its hemodynamic and nonhemodynamic effects. Future developments concerning the use of endothelin receptor antagonists and the role of endothelin in the kidney transplantation setting are discussed.
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Rohmeiss et al. (1999) studied this question.
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